Mouse model of specific fragrance allergy: the haptenous state determines site-specific tolerance or allergy
نویسندگان
چکیده
Methods Cinnamaldehyde (CA) alone, or conjugated with keyhole limpet hemocyanin (CA-KLH) was applied nasally six times on two consecutive days in biweekly intervals. Subsequently, ears were painted with cinnamaldehyde and ear swelling measured after 24 and 48h. Mice were also challenged by oral gavage of 2mg CA and body temperature was measured for 30min. Cytokine profile of stimulated splenocytes as well as CA-specific antibodies and corticosteron-levels were assessed by ELISA.
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